Hotels are notorious for not needing to be in an immediate walkable area to succeed. Virgin is a destination hotel in a hip neighborhood. They will succeed just fine as long as the Dallas Tourism market remains as stable as it has been. Keep in mind Mark Cuban has bought a huge section for his long-term goals as the Dallas Maverick HQ.
The Design District has plenty of offerings with multiple brewery taprooms, Cidercade, Bowling, Pie Tap, Subway, Ascension, Rodeo Goat, Ferris Wheelers, Mama Daughters Diner, Town Hearth, Wheelhouse, Meddlesome Moth, Sassetta, Pakpao Thai Food, The Charles, Buda Juice, Los Lupes. I am not sure whats in Amli Design District tower ground floor anymore(formerly the Hi-Line). There are banks, dry cleaners, 7Eleven, and many antique, designer furniture stores, Dragon Street galleries, Haas Moto Museum and the Haas Sculpture Gallery, Dallas Contemporary etc.
The Design District honestly has almost as much maybe more than most other neighborhoods. You know the Virgin will have a completed list and map for guests most likely in every room. Also, I would not be surprised to see a bike share discount code for guests too.